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Tg(HLA-DR2)#Lfug
Transgene Detail
Nomenclature
Symbol: Tg(HLA-DR2)#Lfug
Name: transgene insertion, Lars Fugger
MGI ID: MGI:5429698
Synonyms: DR2, HLA-DR2
Transgene: Tg(HLA-DR2)#Lfug  Location: unknown  
Transgene
origin
Strain of Origin:  (DBA/2 x C57BL/6)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe murine MHC class II gene Ea promoter drives expression of the human HLA-DRA*0101 and HLA-DRB1*1501 DNAs. The HLA-DRA*0101 and HLA-DRB1*1501 are MS susceptibility genes found in individuals of European descent. (J:134764)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:134764 Madsen LS, et al., A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet. 1999 Nov;23(3):343-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory