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Gsk3atm1.1Tac
Targeted Allele Detail
Nomenclature
Symbol: Gsk3atm1.1Tac
Name: glycogen synthase kinase 3 alpha; targeted mutation 1.1, Taconic
MGI ID: MGI:5427913
Synonyms: GSK-3alphaflox
Gene: Gsk3a  Location: Chr7:25228258-25237851 bp, - strand  Genetic Position: Chr7, 13.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184975
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 4 a via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 2 - 4 floxed. (J:184975)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gsk3a Mutation:  8 strains or lines available
References
Original:  J:184975 Hurtado DE, et al., Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease. J Neurosci. 2012 May 23;32(21):7392-402
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory