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Fgf21tm1Fdl
Targeted Allele Detail
Nomenclature
Symbol: Fgf21tm1Fdl
Name: fibroblast growth factor 21; targeted mutation 1, Francesco De Luca
MGI ID: MGI:5427438
Gene: Fgf21  Location: Chr7:45613886-45615490 bp, - strand  Genetic Position: Chr7, 29.38 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184999
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced part of exon 1, all of exon 2 and the 5' region of exon 3. Mice lack detectable serum levels of the protein. (J:184999)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf21 Mutation:  15 strains or lines available
References
Original:  J:184999 Kubicky RA, et al., Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice. Endocrinology. 2012 May;153(5):2287-95
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory