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Fgf21tm1Fdl
Targeted Allele Detail
Summary
Symbol: Fgf21tm1Fdl
Name: fibroblast growth factor 21; targeted mutation 1, Francesco De Luca
MGI ID: MGI:5427438
Gene: Fgf21  Location: Chr7:45263314-45264914 bp, - strand  Genetic Position: Chr7, 29.38 cM, cytoband B2
Alliance: Fgf21tm1Fdl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184999
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced part of exon 1, all of exon 2 and the 5' region of exon 3. Mice lack detectable serum levels of the protein. (J:184999)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf21 Mutation:  22 strains or lines available
References
Original:  J:184999 Kubicky RA, et al., Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice. Endocrinology. 2012 May;153(5):2287-95
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory