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Cc2d1atm1Bisu
Targeted Allele Detail
Nomenclature
Symbol: Cc2d1atm1Bisu
Name: coiled-coil and C2 domain containing 1A; targeted mutation 1, Bing Su
MGI ID: MGI:5426910
Gene: Cc2d1a  Location: Chr8:84132828-84147936 bp, - strand  Genetic Position: Chr8, 40.32 cM
Small size and hunched back of Cc2d1atm1Bisu/Cc2d1atm1Bisu newborns

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184920
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exons 8 through 14. Western blot analysis confirmed the absence of full-length protein expression in macrophage, neurons and mouse embryonic fibroblast. (J:184920)
Targeting strategy to generate the Cc2d1atm1Bisu allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cc2d1a Mutation:  20 strains or lines available
References
Original:  J:184920 Al-Tawashi A, et al., Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity. J Biol Chem. 2012 Apr 27;287(18):14644-58
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory