Phenotypes associated with this allele

• Allele Symbol: Cc2d1a^tm1Bisu
• Allele Name: targeted mutation 1, Bing Su
• Allele ID: MGI:5426910
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cc2d1a^tm1Bisu/Cc2d1a^tm1Bisu	Not Specified	MGI:5426913

Genotype
MGI:5426913

hm1

• Allelic Composition: Cc2d1a^tm1Bisu/Cc2d1a^tm1Bisu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size and hunched back of Cc2d1a^tm1Bisu/Cc2d1a^tm1Bisu newborns

mortality/aging

neonatal lethality, incomplete penetrance ( J:184920 )

• most mice die within 12 hours of birth

nervous system

abnormal brain vasculature morphology ( J:184920 )

decreased CNS synapse formation ( J:184920 )

• lower total number and density of synapses

abnormal dendrite morphology ( J:184920 )

• reduced length

abnormal neuron physiology ( J:184920 )

• neurons exhibit increased cellular sensitivity to hydrogen peroxide compared with wild-type cells

behavior/neurological

hunched posture ( J:184920 )

growth/size/body

decreased body weight ( J:184920 )

respiratory system

respiratory distress ( J:184920 )

cellular

increased cellular sensitivity to hydrogen peroxide ( J:184920 )

• of neurons

cardiovascular system

abnormal brain vasculature morphology ( J:184920 )