Rr351^tm3Drhi
Targeted Allele Detail

Summary

• Symbol: Rr351^tm3Drhi
• Name: regulatory region 351; targeted mutation 3, Douglas R Higgs
• MGI ID: MGI:5426858
• Synonyms: deltaR3^flox, Nprl3^tm3Drhi
• Gene: Rr351 Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Rr351^tm3Drhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184965
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Hba enhancer element R3 in Nprl3 intron 2 was replaced with a loxP site flanked neomycin resistance gene cassette. The enhancer also serves as a promoter for Nprl3 transcripts with alternative, more downstream, 1st exons. (J:184965)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr351 Mutation: 0 strains or lines available

References

• Original: J:184965 Kowalczyk MS, et al., Intragenic enhancers act as alternative promoters. Mol Cell. 2012 Feb 24;45(4):447-58
• All: 1 reference(s)