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Ago1tm1.1Tara
Targeted Allele Detail
Nomenclature
Symbol: Ago1tm1.1Tara
Name: argonaute RISC catalytic subunit 1; targeted mutation 1.1, Alexander Tarakhovsky
MGI ID: MGI:5319524
Synonyms: Ago1fl
Gene: Ago1  Location: Chr4:126328805-126362376 bp, - strand  Genetic Position: Chr4, 60.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:183622
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting vector containing FRT site flanked NEO cassette and 2 loxP sites that was used to flank exons 13-16 with loxP sites. Flp-mediated recombination removed the neo cassette and left exons 13 through 16 floxed. (J:188988)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ago1 Mutation:  140 strains or lines available
References
Original:  J:183622 Wang D, et al., Quantitative functions of Argonaute proteins in mammalian development. Genes Dev. 2012 Apr 1;26(7):693-704
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory