Ntrk1^tm2.1Lfr
Targeted Allele Detail

Summary

• Symbol: Ntrk1^tm2.1Lfr
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 2.1, Louis F Reichardt
• MGI ID: MGI:5319087
• Synonyms: Ntrk1^tm2.1Par, targeted mutation 2.1, Luis F Parada, TrkAflox
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^tm2.1Lfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183467
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in the promoter region 158 bp upstream of the transcription start site and an FRT flanked neo cassette and loxP site were inserted in intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette. Immunostaining confirmed normal expression of protein in the brain. (J:183467)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 60 strains or lines available

References

• Original: J:183467 Sanchez-Ortiz E, et al., TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. J Neurosci. 2012 Mar 21;32(12):4065-79
• All: 2 reference(s)