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Targeted Allele Detail
Symbol: Kcnk1tm1.1Barh
Name: potassium channel, subfamily K, member 1; targeted mutation 1.1, Jacques Barhanin
MGI ID: MGI:5318213
Synonyms: TWIK-1-
Gene: Kcnk1  Location: Chr8:125995170-126030685 bp, + strand  Genetic Position: Chr8, 73.67 cM
Germline Transmission:  Earliest citation of germline transmission: J:183234
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 2 and a floxed pgk-neo cassette was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. (J:183234)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnk1 Mutation:  15 strains or lines available
Original:  J:183234 Nie X, et al., Expression and insights on function of potassium channel TWIK-1 in mouse kidney. Pflugers Arch. 2005 Dec;451(3):479-88
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory