Phenotypes associated with this allele

• Allele Symbol: Kcnk1^tm1.1Barh
• Allele Name: targeted mutation 1.1, Jacques Barhanin
• Allele ID: MGI:5318213
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnk1^tm1.1Barh/Kcnk1^tm1.1Barh	involves: 129 * C57BL/6 * C57BL/6J * SJL	MGI:5318215

Genotype
MGI:5318215

hm1

• Allelic Composition: Kcnk1^tm1.1Barh/Kcnk1^tm1.1Barh
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal renal phosphate reabsorption ( J:183234 )

• significantly higher fractional renal Pi excretion after 7 days on a low phosphate diet

increased urine phosphate level ( J:183234 )

• significantly higher fractional renal Pi excretion after 7 days on a low phosphate diet

decreased urine flow rate ( J:183234 )

• reduced basal urinary flow rate and reduced response to a vasopressin V2 receptor antagonist

homeostasis/metabolism

decreased circulating phosphate level ( J:183234 )

• significantly lower plasma Pi concentration after 7 days on a low phosphate diet

abnormal renal phosphate reabsorption ( J:183234 )

• significantly higher fractional renal Pi excretion after 7 days on a low phosphate diet

increased urine phosphate level ( J:183234 )

• significantly higher fractional renal Pi excretion after 7 days on a low phosphate diet