Tg(Slc17a8-icre)1Edw
Transgene Detail
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Symbol: |
Tg(Slc17a8-icre)1Edw |
Name: |
transgene insertion 1, Robert H Edwards |
MGI ID: |
MGI:5316477 |
Synonyms: |
VG3-Cre, VGLUT3 Cre BAC |
Transgene: |
Tg(Slc17a8-icre)1Edw Location: unknown
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Alliance: |
Tg(Slc17a8-icre)1Edw page
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(Slc17a8-icre)1Edw expression driven by
1 gene
Transgene expression driven by:
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Mutation details: The C57BL/6 mouse bacterial artificial chromosome (BAC) RP24-88H21, containing only the Slc17a8
locus, was modified by targeting a codon optimized cre recombinase (icre), followed by an SV40 polyA signal, into the ATG start site of theSlc17a8 locus. The modified BAC was microinjected into fertilized FVB/N oocytes and transgenic founders were obtained and crossed to mice expressing a cre-dependent reporter. Activity of icre is seen in interneurons in the hippocampus, cortex, striatum, and cerebellum, with some expression seen in amacrine cells of the inner retina. Two of four founder lines expressed cre, and one line was analyzed further.
(J:182798)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Slc17a8
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:182798 Grimes WN, et al., Genetic targeting and physiological features of VGLUT3+ amacrine cells. Vis Neurosci. 2011 Sep;28(5):381-92 |
All: |
32 reference(s) |
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