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Targeted Allele Detail
Symbol: Ror1tm1.2Meg
Name: receptor tyrosine kinase-like orphan receptor 1; targeted mutation 1.2, Michael E Greenberg
MGI ID: MGI:5315484
Synonyms: Ror1-, Ror1d
Gene: Ror1  Location: Chr4:100095791-100444765 bp, + strand  Genetic Position: Chr4, 45.71 cM, cytoband C6
Rare exencephaly in Ror1tm1.2Meg/Ror1tm1.2Meg mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:182150
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Flp-mediated recombination removed the neo cassette. Exons 3 and 4 were deleted through cre-mediated recombination. Western blot analysis confirms absence of protein expression in homozygous mice. (J:182150)
Generation of the Ror1tm1.1Meg and Ror1tm1.2Meg alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ror1 Mutation:  37 strains or lines available
Original:  J:182150 Ho HY, et al., Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory