Mirc11^tm1Wtsi
Targeted Allele Detail

Summary

• Symbol: Mirc11^tm1Wtsi
• Name: microRNA cluster 11, including Mir23a through Mir24-2; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:5315147
• Synonyms: Mir23a-Mir24-2 cluster 8N2, Mir23a^{tm1(mirKO)Wtsi}, Mirc11^{tm1(mirKO)Wtsi}
• Gene: Mirc11 Location: Chr8:84935147-84935550 bp Genetic Position: Chr8, Syntenic

Mutation origin

• Mutant Cell Lines: mirKO_ES_PuDtk_12F1, mirKO_ES_PuDtk_12F2, mirKO_ES_PuDtk_12F3, mirKO_ES_PuDtk_12F4, mirKO_ES_PuDtk_12F5, mirKO_ES_PuDtk_12F6
• Germline Transmission: Earliest citation of germline transmission: J:258947
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: Sanger miRNA knockouts

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Mir23a, Mir27a, Mir3074-2, and Mir24-2 in this microRNA cluster were replaced via homologous recombination by a puromycin/thymidine kinase fusion gene under the control of EM7/PGK promoters and flanked by LoxP and F3/FRT sites. (J:94077, J:174268)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc11 Mutation: 2 strains or lines available

References

• Original: J:174268 Prosser HM, et al., A resource of vectors and ES cells for targeted deletion of microRNAs in mice. Nat Biotechnol. 2011 Aug 7;29(9):840-5
• All: 4 reference(s)