Tg(Mbp/Prnp)640Zbz
Transgene Detail

Summary

• Symbol: Tg(Mbp/Prnp)640Zbz
• Name: transgene insertion 640, Universitatsspital Zurich
• MGI ID: MGI:5314788
• Synonyms: MBP-PrP, tg640, TgN640[MBP]
• Transgene: Tg(Mbp/Prnp)640Zbz Location: unknown
• Alliance: Tg(Mbp/Prnp)640Zbz page

Transgene origin

• Strain of Origin: B6;129S7-Prnp^tm1Cwe

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mbp/Prnp)640Zbz expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mbp (MGI:96925)	Transgene codes for a fusion prrotein of Mbp and Prnp.
  mouse	Prnp (MGI:97769)	Transgene codes for a fusion prrotein of Mbp and Prnp.

• Mutation details: The transgene comprises, in order, a 1.3 kb fragment of the mouse myelin basic protein (Mbp) gene that includes the promoter, mRNA cap site and 5' noncoding sequence; a mouse Mbp cDNA containing the full coding sequence for the smallest (14kDa) MBP protein; the 760 bp third exon of the mouse prion protein (Prnp) gene - which contains the entire Prnp open reading frame - flanked by two copies of the rabbit beta-globin second intron; and polyadenylation signals from the rabbit beta-globin and SV40 early region genes. (J:97275)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

The transgene was generated and maintained in a Prnp-null (Prnp^tm1Cwe/Prnp^tm1Cwe) genetic background. (J:97275)

References

• Original: J:97275 Prinz M, et al., Intrinsic resistance of oligodendrocytes to prion infection. J Neurosci. 2004 Jun 30;24(26):5974-81
• All: 2 reference(s)