Vamp7^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Vamp7^tm1.1Ics
• Name: vesicle-associated membrane protein 7; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5313432
• Gene: Vamp7 Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Vamp7^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181320
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP and FRT flanked neo cassette was inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 3. Full length and TIVc isoform sequence and protein expression are absent in null mice. (J:181320)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vamp7 Mutation: 2 strains or lines available

References

• Original: J:181320 Danglot L, et al., Absence of TI-VAMP/Vamp7 leads to increased anxiety in mice. J Neurosci. 2012 Feb 8;32(6):1962-8
• All: 5 reference(s)