Vamp7 MGI Mouse Gene Detail - MGI:1096399 - vesicle-associated membrane protein 7

Vamp7 Gene Detail

Symbol

Vamp7
Name

vesicle-associated membrane protein 7
Synonyms

Sybl1, VAMP-7

Feature Type

protein coding gene
IDs

MGI:1096399
NCBI Gene: 20955
Alliance

gene page

Sequence Map

Genome coordinates not available from the current reference assembly.
This gene is annotated to Unlocalized Scaffold from chromosome X, MMCHRX_RANDOM_CTG2 (GL456233.2, NT_165789.3) of Assembly GRCm39. UCSC coordinates are chrX_GL456233_random:10737-39191 bp, - strand.

Genetic Map

Chromosome X, Syntenic
Mapping Data

3 experiments

PCR

1

Human Ortholog

VAMP7, vesicle associated membrane protein 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VAMP7, vesicle associated membrane protein 7
Synonyms

SYBL1, TIVAMP, TI-VAMP, VAMP-7
Links

HGNC:11486

NCBI Gene ID: 6845

neXtProt AC: NX_P51809

UniProt: P51809
Chr Location

XYq28 and Yq12

MGI Vertebrate Homology

Vamp7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VAMP7

less

Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Find Mice (IMSR)

2 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display an increased anxiety related response, increased circulating glycerol level, decreased body temperature, and decreased brain weight.

less

All GO Annotations

79
GO References

24

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

21
Tissues

15
cDNA Data

63
Literature Summary

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase vamp7

less

All Sequences

21
RefSeq

9
UniProt

2

NCBI Gene

20955

			Length	Strain/Species	Flank
genomic	GL456233	GenBank \| ENA \| DDBJ \| MGI Sequence Detail	559103	C57BL/6J	± kb
transcript	NM_011515	RefSeq \| MGI Sequence Detail	2572	ZRU/MplStud
polypeptide	P70280	UniProt \| EBI \| MGI Sequence Detail	220	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000017253 vesicle-associated membrane protein 7

(term hierarchy)
PDB

2VX8, 4AFI, 4B93
InterPro Domains

IPR010908 Longin domain

IPR011012 Longin-like domain superfamily

IPR001388 Synaptobrevin-like

IPR042855 v-SNARE, coiled-coil homology domain

less

All nucleic 65

Genomic 1

cDNA 63

Primer pair 1

Microarray probesets 4

Summaries

All 68

Developmental Gene Expression 10

Gene Ontology 24

Phenotypes 11
Earliest

J:43563 D'Esposito M, et al., Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. Hum Mol Genet. 1997 Oct;6(11):1917-23
Latest

J:343146 Xu H, et al., Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1. Nat Neurosci. 2023 Oct;26(10):1685-1700

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23