About   Help   FAQ
Vamp7 Gene Detail
Summary
  • Symbol
    Vamp7
  • Name
    vesicle-associated membrane protein 7
  • Synonyms
    Sybl1, VAMP-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096399
    NCBI Gene: 20955
  • Alliance
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • This gene is annotated to Unlocalized Scaffold from chromosome X, MMCHRX_RANDOM_CTG2 (GL456233.2, NT_165789.3) of Assembly GRCm39. UCSC coordinates are chrX_GL456233_random:10737-39191 bp, - strand.
  • Genetic Map
    Chromosome X, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • PCR
Homology
more
  • Human Ortholog
    VAMP7, vesicle associated membrane protein 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VAMP7, vesicle associated membrane protein 7
  • Synonyms
    SYBL1, TI-VAMP, TIVAMP, VAMP-7
  • Links
    NCBI Gene ID: 6845
    neXtProt AC: NX_P51809
    UniProt: P51809

  • Chr Location
    XYq28 and Yq12

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display an increased anxiety related response, increased circulating glycerol level, decreased body temperature, and decreased brain weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic GL456233 GenBank | ENA | DDBJ | MGI Sequence Detail 559103 C57BL/6J ±  kb
    transcript NM_011515 RefSeq | MGI Sequence Detail 2572 ZRU/MplStud  
    polypeptide P70280 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 63
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 10
      Gene Ontology 24
      Phenotypes 11
    • Earliest
      J:43563 D'Esposito M, et al., Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. Hum Mol Genet. 1997 Oct;6(11):1917-23
    • Latest
      J:343146 Xu H, et al., Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1. Nat Neurosci. 2023 Oct;26(10):1685-1700

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    09/24/2024
    MGI 6.24
    The Jackson Laboratory