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Targeted Allele Detail
Symbol: Xpatm1Gvh
Name: xeroderma pigmentosum, complementation group A; targeted mutation 1, Gijsbertus T J van der Horst
MGI ID: MGI:5312129
Synonyms: Xpac
Gene: Xpa  Location: Chr4:46155347-46196311 bp, - strand  Genetic Position: Chr4, 24.49 cM, cytoband C2
Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Gvh/Xpatm1Hvs Tg(CAG-cre)13Miya/0 mice are severely reduced in size

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:179808
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA construct replaced exon 4. This construct contains (5' to 3'): loxP, cDNA encoding exons 4-6, hygro, loxP, splice acceptor, Murfi cassette, IRES, lacZ and GFP. (J:179808)
Generation of the Xpatm1Gvh allele
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xpa Mutation:  12 strains or lines available
Original:  J:179808 Jaarsma D, et al., Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology. PLoS Genet. 2011 Dec;7(12):e1002405
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory