Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma
Transgene Detail

Summary

• Symbol: Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma
• Name: transgene insertion 1, Daniel M Altmann
• MGI ID: MGI:5312109
• Synonyms: HLA-A2/DR, HLA-DR, HLA-DR1, Tg(HLA-DR1)
• Transgene: Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma Location: unknown
• Alliance: Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dma expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HLA-DRA (3122)

  H2-Ea

  (MGI:95900)

• Mutation details: This transgene was generated by coinjection of cosmid inserts of ~24 and ~22 kb, respectively, containing the complete human major histocompatibility (MHC) class II gene alleles HLA-DRA*0101 and HLA-DRB1*0101, each with several kilobases of flanking sequence. The resulting transgenic mice express human serotype HLA-DR1. (J:181600)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available

References

• Original: J:181600 Altmann DM, et al., The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4. J Exp Med. 1995 Mar 1;181(3):867-75
• All: 21 reference(s)