About   Help   FAQ
Asltm1Brle
Targeted Allele Detail
Nomenclature
Symbol: Asltm1Brle
Name: argininosuccinate lyase; targeted mutation 1, Brendan Lee
MGI ID: MGI:5308970
Synonyms: AslNeo
Gene: Asl  Location: Chr5:130011258-130029247 bp, - strand  Genetic Position: Chr5, 68.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180208
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted downstream of exon 7. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 9. Western blot analysis confirmed a reduction in protein expression. This allele is hypomorphic. (J:180208)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Asl Mutation:  10 strains or lines available
References
Original:  J:180208 Erez A, et al., Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med. 2011 Dec;17(12):1619-26
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/15/2018
MGI 6.12
The Jackson Laboratory