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Targeted Allele Detail
Symbol: Pitx2tm1.1Dmm
Name: paired-like homeodomain transcription factor 2; targeted mutation 1.1, Donna M Martin
MGI ID: MGI:5308807
Synonyms: Pitx2Taulacz, Pitx2tlz
Gene: Pitx2  Location: Chr3:129199878-129219591 bp, + strand  Genetic Position: Chr3, 57.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:181058
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 4 was replaced with a splice acceptor, stop codon, IRES, bovine MAPT fused to lacZ (tau-lacZ) and floxed neo cassette. Cre-mediated recombination removed the neo cassette. Immunofluorescence confirmed the absence of protein expression. (J:181058)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:  11 strains or lines available
Original:  J:181058 Skidmore JM, et al., A novel TaulacZ allele reveals a requirement for Pitx2 in formation of the mammillothalamic tract. Genesis. 2012 Jan;50(1):67-73
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory