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Hspa4tm1Imad
Targeted Allele Detail
Nomenclature
Symbol: Hspa4tm1Imad
Name: heat shock protein 4; targeted mutation 1, Ibrahim M Adham
MGI ID: MGI:5308719
Gene: Hspa4  Location: Chr11:53259814-53300457 bp, - strand  Genetic Position: Chr11, 31.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180915
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3 kb genomic region including exon 1 was replaced with a pgk-neo cassette via homologous recombination. RT-PCR and western blot analysis confirmed the absence of expression in testes from homozygous mice. (J:180915)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspa4 Mutation:  60 strains or lines available
References
Original:  J:180915 Held T, et al., Heat-shock protein HSPA4 is required for progression of spermatogenesis. Reproduction. 2011 Jul;142(1):133-44
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory