Hspa4^tm1Imad
Targeted Allele Detail

Summary

• Symbol: Hspa4^tm1Imad
• Name: heat shock protein 4; targeted mutation 1, Ibrahim M Adham
• MGI ID: MGI:5308719
• Gene: Hspa4 Location: Chr11:53150641-53191284 bp, - strand Genetic Position: Chr11, 31.91 cM
• Alliance: Hspa4^tm1Imad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180915
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3 kb genomic region including exon 1 was replaced with a pgk-neo cassette via homologous recombination. RT-PCR and western blot analysis confirmed the absence of expression in testes from homozygous mice. (J:180915)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspa4 Mutation: 74 strains or lines available

References

• Original: J:180915 Held T, et al., Heat-shock protein HSPA4 is required for progression of spermatogenesis. Reproduction. 2011 Jul;142(1):133-44
• All: 3 reference(s)