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Targeted Allele Detail
Symbol: Mavstm1Camb
Name: mitochondrial antiviral signaling protein; targeted mutation 1, John C Cambier
MGI ID: MGI:5308082
Synonyms: VISA-
Gene: Mavs  Location: Chr2:131234063-131248025 bp, + strand  Genetic Position: Chr2, 63.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:180356
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo cassette replaced the sequence between the translation initiation site in exon 2 through part of exon 5. Western blot analysis confirmed the absence of protein expression in splenic cells. (J:180356)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mavs Mutation:  25 strains or lines available
Original:  J:180356 Xu LG, et al., VISA is required for B cell expression of TLR7. J Immunol. 2012 Jan 1;188(1):248-58
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory