Phenotypes associated with this allele

• Allele Symbol: Mavs^tm1Camb
• Allele Name: targeted mutation 1, John C Cambier
• Allele ID: MGI:5308082
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mavs^tm1Camb/Mavs^tm1Camb	involves: 129S6/SvEvTac * C57BL/6	MGI:5308089

Genotype
MGI:5308089

hm1

• Allelic Composition: Mavs^tm1Camb/Mavs^tm1Camb
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal B cell calcium ion homeostasis ( J:180356 )

• anti-IgM-stimulated B cells exhibit slightly elevated calcium flux compared with wild-type mice

immune system

decreased B cell proliferation ( J:180356 )

• in response to LOX and R848 but not CpG

abnormal B cell calcium ion homeostasis ( J:180356 )

• anti-IgM-stimulated B cells exhibit slightly elevated calcium flux compared with wild-type mice

decreased interleukin-12 secretion ( J:180356 )

• in B cells from LOX-treated mice

decreased tumor necrosis factor secretion ( J:180356 )

• in B cells from LOX-treated mice

hematopoietic system

decreased B cell proliferation ( J:180356 )

• in response to LOX and R848 but not CpG

abnormal B cell calcium ion homeostasis ( J:180356 )

• anti-IgM-stimulated B cells exhibit slightly elevated calcium flux compared with wild-type mice

cellular

decreased B cell proliferation ( J:180356 )

• in response to LOX and R848 but not CpG