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Targeted Allele Detail
Symbol: Rr7tm3.1Kio
Name: regulatory region 7; targeted mutation 3.1, Dimitris Kioussis
MGI ID: MGI:5305062
Synonyms: CD8/lxLCRlx
Gene: Rr7  Location: unknown  Genetic Position: Chr6, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:179326
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Allele Type:    Targeted (Modified regulatory region)
Mutation:    Insertion
Mutation detailsA neo cassette with a 5' loxP site and floxed human CD2 locus control region were inserted between the DNase I hypersensitivity clusters cII and cIII of the CD8 locus control region. Cre-mediated recombination removed the neo cassette. (J:179326)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr7 Mutation:  0 strains or lines available
Original:  J:179326 Menzel U, et al., Modulation of the murine CD8 gene complex following the targeted integration of human CD2-locus control region sequences. J Immunol. 2011 Oct 1;187(7):3712-20
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory