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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr7tm3.1Kio
targeted mutation 3.1, Dimitris Kioussis
MGI:5305062
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Rr7tm3.1Kio/Rr7+ B6.129S4-Rr7tm3.1Kio MGI:5305072
cn2
 		Rr7tm3.1Kio/Rr7+
Tg(CD2-icre)4Kio/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca MGI:5305075
cn3
 		Rr7tm3.1Kio/Rr7+
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca MGI:5305077
cn4
 		Rr7tm3.1Kio/Rr7+
Tg(Lck-cre)#Nik/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5305076


Genotype
MGI:5305072
ht1
Allelic
Composition		 Rr7tm3.1Kio/Rr7+
Genetic
Background		 B6.129S4-Rr7tm3.1Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:179326 )
• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8
• however, the number of CD4+(CD8+) decreases with age due to thymus involution

immune system
abnormal CD4-positive, alpha beta T cell morphology ( J:179326 )
• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8
• however, the number of CD4+(CD8+) decreases with age due to thymus involution




Genotype
MGI:5305075
cn2
Allelic
Composition		 Rr7tm3.1Kio/Rr7+
Tg(CD2-icre)4Kio/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr7tm3.1Kio mutation (0 available); any Rr7 mutation (0 available)
Tg(CD2-icre)4Kio mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:179326 )
N
• mice exhibit normal expression of Cd8a and Cd8b




Genotype
MGI:5305077
cn3
Allelic
Composition		 Rr7tm3.1Kio/Rr7+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Rr7tm3.1Kio mutation (0 available); any Rr7 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:179326 )
N
• mice exhibit normal expression of Cd8a and Cd8b




Genotype
MGI:5305076
cn4
Allelic
Composition		 Rr7tm3.1Kio/Rr7+
Tg(Lck-cre)#Nik/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:179326 )
• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8
• however, the number of CD4+(CD8+) decreases with age compared with Rr7tm3.1Kio heterozygotes due to cre-mediated removal of the CD2 LCR

immune system
abnormal CD4-positive, alpha beta T cell morphology ( J:179326 )
• unlike wild-type cells, a portion of peripheral CD4+ T cells expressing CD8
• however, the number of CD4+(CD8+) decreases with age compared with Rr7tm3.1Kio heterozygotes due to cre-mediated removal of the CD2 LCR




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory