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Targeted Allele Detail
Symbol: Ppm1atm1.1Xya
Name: protein phosphatase 1A, magnesium dependent, alpha isoform; targeted mutation 1.1, Xiao Yang
MGI ID: MGI:5304773
Gene: Ppm1a  Location: Chr12:72761211-72799819 bp, + strand  Genetic Position: Chr12, 30.26 cM, cytoband C3
Delayed re-epithelialization during wound healing in Ppm1atm1.1Xya/Ppm1atm1.1Xya mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:178733
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre-mediated recombination of Ppm1atm1Xya removed exons 2 and 3. RT-PCR confirmed the absence of transcript expression in the liver, stomach, and skin. (J:178733)
Generation of the Ppm1atm1Xya and Ppm1atm1.1Xya alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppm1a Mutation:  16 strains or lines available
Original:  J:178733 Yang X, et al., Delayed Re-epithelialization in Ppm1a Gene-deficient Mice Is Mediated by Enhanced Activation of Smad2. J Biol Chem. 2011 Dec 9;286(49):42267-73
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory