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Ppm1atm1.1Xya
Targeted Allele Detail
Nomenclature
Symbol: Ppm1atm1.1Xya
Name: protein phosphatase 1A, magnesium dependent, alpha isoform; targeted mutation 1.1, Xiao Yang
MGI ID: MGI:5304773
Gene: Ppm1a  Location: Chr12:72761211-72799819 bp, + strand  Genetic Position: Chr12, 30.26 cM, cytoband C3
Delayed re-epithelialization during wound healing in Ppm1atm1.1Xya/Ppm1atm1.1Xya mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178733
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination of Ppm1atm1Xya removed exons 2 and 3. RT-PCR confirmed the absence of transcript expression in the liver, stomach, and skin. (J:178733)
Generation of the Ppm1atm1Xya and Ppm1atm1.1Xya alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppm1a Mutation:  6 strains or lines available
References
Original:  J:178733 Yang X, et al., Delayed Re-epithelialization in Ppm1a Gene-deficient Mice Is Mediated by Enhanced Activation of Smad2. J Biol Chem. 2011 Dec 9;286(49):42267-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory