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Glrx2tm1Ysh
Targeted Allele Detail
Summary
Symbol: Glrx2tm1Ysh
Name: glutaredoxin 2; targeted mutation Ye-Shih Ho
MGI ID: MGI:5301815
Gene: Glrx2  Location: Chr1:143614787-143625416 bp, + strand  Genetic Position: Chr1, 62.53 cM, cytoband F
Alliance: Glrx2tm1Ysh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178448
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was deleted via homologous recombination. A transcript lacking exon 2 is detected in homozygous mice but western blot analysis did not detect any protein in tissues from homozygous mice. (J:178448)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Glrx2 Mutation:  20 strains or lines available
References
Original:  J:178448 Wu H, et al., Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells. Free Radic Biol Med. 2011 Dec 1;51(11):2108-17
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory