All Phenotypes Glrx2<tm1Ysh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Glrx2^tm1Ysh
targeted mutation Ye-Shih Ho
MGI:5301815

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glrx2^tm1Ysh/Glrx2^tm1Ysh	involves: 129 * C57BL/6	MGI:5301816

Allelic Composition	Glrx2^tm1Ysh/Glrx2^tm1Ysh
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glrx2^tm1Ysh mutation (0 available); any Glrx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye physiology ( J:178448 )

• cultured primary lens epithelial cells show more severe damage, more severe GSH depletion, and more severe suppression of ATP production following H2O2 induced oxidative stress

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:178448 )

• elevated glutathionylation in mitochondrial fractions from liver

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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