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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glrx2tm1Ysh
targeted mutation Ye-Shih Ho
MGI:5301815
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Glrx2tm1Ysh/Glrx2tm1Ysh involves: 129 * C57BL/6 MGI:5301816


Genotype
MGI:5301816
hm1
Allelic
Composition		 Glrx2tm1Ysh/Glrx2tm1Ysh
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glrx2tm1Ysh mutation (0 available); any Glrx2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye physiology ( J:178448 )
• cultured primary lens epithelial cells show more severe damage, more severe GSH depletion, and more severe suppression of ATP production following H2O2 induced oxidative stress

homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:178448 )
• elevated glutathionylation in mitochondrial fractions from liver




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory