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Targeted Allele Detail
Symbol: Scribtm1.2Phum
Name: scribbled planar cell polarity; targeted mutation 1.2, Patrick O Humbert
MGI ID: MGI:5299427
Gene: Scrib  Location: Chr15:76047162-76069784 bp, - strand  Genetic Position: Chr15, 35.29 cM
Craniorachischisis in Scribtm1.2Phum/Scribtm1.2Phum mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:178461
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre-mediated recombination removed exons 4 through 13 from Scribtm1.1Phum. Western blot analysis confirmed the absence of protein expression in embryos. (J:178461)
Generation of the Scribtm1.1Phum and Scribtm1.2Phum alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scrib Mutation:  32 strains or lines available
Original:  J:178461 Pearson HB, et al., SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest. 2011 Nov 1;121(11):4257-67
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory