reproductive system
|
• however, treatment with MEK inhibitor PD0325901 restores normal prostate weight
|
|
• in 7 of 10 mice with a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis
|
|
• a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis
|
neoplasm
|
• 43% incidence of lung adenomas by 540 days of age
• lung tumors range from atypical adenomatous hyperplasia to focal grade 3 lesions
|
|
• lung adenomas have characteristics of non-small cell lung cancer
|
|
• at 540 days, 4 of 8 mice develop lung adenocarcinomas unlike wild-type mice
|
endocrine/exocrine glands
|
• however, treatment with MEK inhibitor PD0325901 restores normal prostate weight
|
|
• in 7 of 10 mice with a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis
|
|
• at 540 days, one mouse exhibit pancreatic preinvasive ductal lesions unlike wild-type mice
|
|
• a 4.8-fold increase in cell proliferation without a change in the rate of apoptosis
|
respiratory system
|
• 43% incidence of lung adenomas by 540 days of age
• lung tumors range from atypical adenomatous hyperplasia to focal grade 3 lesions
|
|
• lung adenomas have characteristics of non-small cell lung cancer
|
|
• at 540 days, 4 of 8 mice develop lung adenocarcinomas unlike wild-type mice
|