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Targeted Allele Detail
Symbol: Mapttm1(Setdb1)Akba
Name: microtubule-associated protein tau; targeted mutation 1, Schahram Akbarian
MGI ID: MGI:5298877
Synonyms: tauSetdb1
Gene: Mapt  Location: Chr11:104231390-104332090 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:178512
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted
Mutation:    Insertion
Mutation detailsThe myc-tagged mouse cDNA and a neo cassette were inserted downstream of the start codon in exon 2. Western blot analysis confirmed protein expression in the cerebral cortex, striatum, hippocampus, cerebellum, thalamus, hypothalamus, peri-aqueductal gray, and substantia nigra. (J:178512)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:  401 strains or lines available
Original:  J:178512 Jiang Y, et al., Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Neuropharmacology. 2011 Jun;60(7-8):1088-97
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory