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Nkx2-2tm2.1Suss
Targeted Allele Detail
Nomenclature
Symbol: Nkx2-2tm2.1Suss
Name: NK2 homeobox 2; targeted mutation 2.1, Lori Sussel
MGI ID: MGI:5297810
Synonyms: Nkx2.2TNmut
Gene: Nkx2-2  Location: Chr2:147177546-147194243 bp, - strand  Genetic Position: Chr2, 72.63 cM, cytoband H
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177838
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (RMCE-ready)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsRecombination mediated cassette exchange (RMCE) into Nkx2-2tm1Suss inserted nucleotide substitutions that result in several amino acid substitutions in the tinman (TN) domain (TGFSVKDILDLP to TGFAAAAIVDLP). An FRT-flanked neo cassette used for selection was removed by flp-mediated recombination. (J:177838)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-2 Mutation:  2 strains or lines available
References
Original:  J:177838 Papizan JB, et al., Nkx2.2 repressor complex regulates islet beta-cell specification and prevents beta-to-alpha-cell reprogramming. Genes Dev. 2011 Nov 1;25(21):2291-305
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory