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Psen1tm1.1Tcs
Targeted Allele Detail
Nomenclature
Symbol: Psen1tm1.1Tcs
Name: presenilin 1; targeted mutation 1.1, Takaomi Saido
MGI ID: MGI:5292236
Synonyms: PS1-R278I
Gene: Psen1  Location: Chr12:83688203-83735199 bp, + strand  Genetic Position: Chr12, 38.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175901
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 8 was replaced with a neo cassette and a modified exon 8 in which a G to T mutation results in the amino acid substitution of isoleucine for arginine at position 278 (R278I). Cre-mediated recombination removed the neo cassette. (J:175901)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psen1 Mutation:  21 strains or lines available
References
Original:  J:175901 Saito T, et al., Potent amyloidogenicity and pathogenicity of Abeta43. Nat Neurosci. 2011 Aug;14(8):1023-32
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory