All Phenotypes Psen1<tm1.1Tcs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Psen1^tm1.1Tcs
targeted mutation 1.1, Takaomi C Saido
MGI:5292236

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psen1^tm1.1Tcs/Psen1^tm1.1Tcs	involves: C57BL/6J	MGI:5292243
ht2	Psen1^tm1Shn/Psen1^tm1.1Tcs	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5292244
cx3	Psen1^tm1.1Tcs/Psen1^tm1.1Tcs Tg(APPSWE)2576Kha/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:5292246

Allelic Composition	Psen1^tm1.1Tcs/Psen1^tm1.1Tcs
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1^tm1.1Tcs mutation (0 available); any Psen1 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:175901 )

• at E15 to E18

limbs/digits/tail

abnormal limb development ( J:175901 )

• limb ateliosis

short tail ( J:175901 )

• stubby

cardiovascular system

hemorrhage ( J:175901 )

• in the central nervous system

growth/size/body

decreased fetal size ( J:175901 )

Allelic Composition	Psen1^tm1Shn/Psen1^tm1.1Tcs
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1^tm1.1Tcs mutation (0 available); any Psen1 mutation (61 available)
Psen1^tm1Shn mutation (2 available); any Psen1 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:175901 )

limbs/digits/tail

abnormal limb development ( J:175901 )

• limb ateliosis

short tail ( J:175901 )

• stubby

cardiovascular system

hemorrhage ( J:175901 )

• in the central nervous system

growth/size/body

decreased fetal size ( J:175901 )

Allelic Composition	Psen1^tm1.1Tcs/Psen1^tm1.1Tcs Tg(APPSWE)2576Kha/0
Genetic Background	involves: C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1^tm1.1Tcs mutation (0 available); any Psen1 mutation (61 available)
Tg(APPSWE)2576Kha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal short-term spatial reference memory ( J:175901 )

• at 3 to 4 months in a Y-maze test

nervous system

astrocytosis ( J:175901 )

• at 9 months

amyloid beta deposits ( J:175901 )

• beginning at 6 months, earlier than in Tg(APPSWE)2576Kha mice at 12 months

• fewer plaques than in Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSWE)2576Kha mice

homeostasis/metabolism

amyloid beta deposits ( J:175901 )

• beginning at 6 months, earlier than in Tg(APPSWE)2576Kha mice at 12 months

• fewer plaques than in Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSWE)2576Kha mice

cellular

astrocytosis ( J:175901 )

• at 9 months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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