Dp(2Hoxd11)6Ddu
Targeted Allele Detail

Summary

• Symbol: Dp(2Hoxd11)6Ddu
• Name: duplication, Chr 2, Denis Duboule 6
• MGI ID: MGI:5289967
• Synonyms: dup(11), HoxD^Dup(11)Ddu
• Gene: Dp(2Hoxd11)6Ddu Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80090
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Duplication
• Dp(2Hoxd11)6Ddu involves 1 genes/genome features (Hoxd11) View all
• Mutation details: Duplication of Hoxd11 was accomplished via trans-allelic meiotic recombination (TAMERE): Cre recombinase-mediated recombination occurred in vivo between loxP sites that had been introduced, independently, by homologous recombination in embryonic stem cells into the intergenic region upstream of Hoxd11 on one copy and the intergenic region downstream of Hoxd11 on another copy of Chr 2. The resulting unequal recombination produced the present duplication and a reciprocal deletion of Hoxd11. (J:80090)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dp(2Hoxd11)6Ddu Mutation: 1 strain or line available

References

• Original: J:80090 Kmita M, et al., Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs. Nature. 2002 Nov 14;420(6912):145-50
• All: 1 reference(s)