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Ndrg4tm1Myta
Targeted Allele Detail
Nomenclature
Symbol: Ndrg4tm1Myta
Name: N-myc downstream regulated gene 4; targeted mutation 1, Toshiyuki Miyata
MGI ID: MGI:5287887
Gene: Ndrg4  Location: Chr8:95676980-95715119 bp, + strand  Genetic Position: Chr8, 47.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175573
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn inverted floxed pST-neoB cassette was inserted into exon 6 via homologous recombination. Western blot analysis confirmed the absence of expression of all protein isoforms in the brains of homozygous mice. (J:175573)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndrg4 Mutation:  13 strains or lines available
References
Original:  J:175573 Yamamoto H, et al., NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia. J Biol Chem. 2011 Jul 22;286(29):26158-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/23/2017
MGI 6.09
The Jackson Laboratory