Phenotypes associated with this allele

• Allele Symbol: Ndrg4^tm1Myta
• Allele Name: targeted mutation 1, Toshiyuki Miyata
• Allele ID: MGI:5287887
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndrg4^tm1Myta/Ndrg4^tm1Myta	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5287889

Genotype
MGI:5287889

hm1

• Allelic Composition: Ndrg4^tm1Myta/Ndrg4^tm1Myta
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:175573 )

• in a morris water maze escape latency to the hidden platform is significantly longer after the first trial compared to wild-type controls

nervous system

increased susceptibility to ischemic brain injury ( J:175573 )

• after, but not during, middle cerebral artery occlusion regional cerebral blood flow is lower than in similarly treated wild type mice

increased cerebral infarct size ( J:175573 )

• following middle cerebral artery occlusion

abnormal brain morphology ( J:175573 )

• significant decrease in BDNF levels in the brain

• however, the levels of other neurotrophins are normal

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:175573 )

• after, but not during, middle cerebral artery occlusion regional cerebral blood flow is lower than in similarly treated wild type mice

increased cerebral infarct size ( J:175573 )

• following middle cerebral artery occlusion