About   Help   FAQ
Myh9tm8.1Rsad
Targeted Allele Detail
Nomenclature
Symbol: Myh9tm8.1Rsad
Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 8, Robert S Adelstein
MGI ID: MGI:5285645
Synonyms: Agfp, GFP-NMHCII-A, GFP-NMII-A
Gene: Myh9  Location: Chr15:77760587-77842175 bp, - strand  Genetic Position: Chr15, 36.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175367
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA cDNA encoding enhanced green fluorescent protein was inserted 5' of the initiating ATG codon in exon 2 and a PGK-neor cassette into intron 2 of the myosin, heavy polypeptide 9, non-muscle (Myh9) gene. The selection cassette has been deleted by Cre recombinase-mediated excision. Immunoblot analysis demonstrates that levels of wild-type and EGFP-tagged MYH9 protein are similar in lungs of heterozygous mutant mice. (J:175367)
Inheritance:    Semidominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myh9 Mutation:  222 strains or lines available
References
Original:  J:175367 Zhang Y, et al., Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. Blood. 2012;119(1):238-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/05/2017
MGI 6.11
The Jackson Laboratory