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Targeted Allele Detail
Symbol: Myh9tm8.1Rsad
Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 8, Robert S Adelstein
MGI ID: MGI:5285645
Synonyms: Agfp, GFP-NMHCII-A, GFP-NMII-A
Gene: Myh9  Location: Chr15:77760587-77842175 bp, - strand  Genetic Position: Chr15, 36.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:175367
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA cDNA encoding enhanced green fluorescent protein was inserted 5' of the initiating ATG codon in exon 2 and a PGK-neor cassette into intron 2 of the myosin, heavy polypeptide 9, non-muscle (Myh9) gene. The selection cassette has been deleted by Cre recombinase-mediated excision. Immunoblot analysis demonstrates that levels of wild-type and EGFP-tagged MYH9 protein are similar in lungs of heterozygous mutant mice. (J:175367)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myh9 Mutation:  153 strains or lines available
Original:  J:175367 Zhang Y, et al., Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. Blood. 2012;119(1):238-5
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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