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Targeted Allele Detail
Symbol: Myh9tm7.1Rsad
Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 7.1, Robert S Adelstein
MGI ID: MGI:5285643
Synonyms: AD1424N, NMHCII-A D1424N
Gene: Myh9  Location: Chr15:77760587-77842175 bp, - strand  Genetic Position: Chr15, 36.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:175367
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
Mutation detailsThe endogenous myosin, heavy polypeptide 9, non-muscle (Myh9) gene was modified by a codon substitution (GAC>AAT) in exon 31 that replaces aspartic acid with asparagine at amino acid position 1424, in the rod region of the protein (D1424N), and by insertion of a loxP flanked PGK-neomycin resistance cassette into the following intron. The selection cassette has been deleted by Cre recombinase-mediated excision. Immunoblot analysis demonstrates that levels of MYH9 protein are similar in lungs of homozygous mutant, heterozygous and wild-type mice. (J:175367)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh9 Mutation:  222 strains or lines available
Original:  J:175367 Zhang Y, et al., Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. Blood. 2012;119(1):238-5
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory