Rest^tm1.1Jhsi
Targeted Allele Detail

Summary

• Symbol: Rest^tm1.1Jhsi
• Name: RE1-silencing transcription factor; targeted mutation 1.1, Jenny Hsieh
• MGI ID: MGI:5141103
• Synonyms: REST/NRSF^loxP
• Gene: Rest Location: Chr5:77413338-77434279 bp, + strand Genetic Position: Chr5, 41.61 cM
• Alliance: Rest^tm1.1Jhsi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174056
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed. (J:174056)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rest Mutation: 95 strains or lines available

References

• Original: J:174056 Gao Z, et al., The Master Negative Regulator REST/NRSF Controls Adult Neurogenesis by Restraining the Neurogenic Program in Quiescent Stem Cells. J Neurosci. 2011 Jun 29;31(26):9772-86
• All: 7 reference(s)