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Pdgfrbtm14(Pdgfrb)Sor
Targeted Allele Detail
Nomenclature
Symbol: Pdgfrbtm14(Pdgfrb)Sor
Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 14, Philippe Soriano
MGI ID: MGI:5140883
Synonyms: PDGFRbeta(S)K
Gene: Pdgfrb  Location: Chr18:61045150-61085061 bp, + strand  Genetic Position: Chr18, 34.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173602
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced with a splice acceptor, floxed neo/stop cassette, and the mouse cDNA with nucleotide substitution(s) that results in the amino acid substitution of valine for aspartic acid at position 849 (D849V). This mutation is an activating mutation. (J:173602)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdgfrb Mutation:  18 strains or lines available
References
Original:  J:173602 Olson LE, et al., PDGFRbeta Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development. Dev Cell. 2011 Jun 14;20(6):815-26
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory