Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrbtm14(Pdgfrb)Sor mutation
(1 available);
any
Pdgfrb mutation
(84 available)
Tg(Prm-cre)70Og mutation
(0 available)
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mortality/aging
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• authors state that the postnatal phenotype is indistinguishable from epiblast-specific cre activation of the floxed allele
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growth/size/body
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• authors state that the postnatal phenotype is indistinguishable from epiblast-specific cre activation of the floxed allele
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mortality/aging
growth/size/body
mortality/aging
cardiovascular system
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• during the second week, mice exhibit thickening of the ascending aorta compared with wild-type mice
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adipose tissue
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N |
• at P13, mice exhibit normal interscapular brown adipose tissue
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• at P13, inguinal white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice
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• at P13, only rudimentary mesenteric adipose depots are detected compared to in wild-type mice
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• at P9, white adipose tissue exhibit a 1.5-fold increase in the stromal vascular fraction compared with wild-type tissue
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• subcutaneous mesenchymal cells exhibit reduced white adipocyte differentiation in vitro compared with wild-type cells
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• at P13, inguinal and subcutaneous white adipose tissues contain reduced lipids but higher cell density compared to in wild-type mice
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• at P13, subcutaneous white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice
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growth/size/body
integument
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• at P13, subcutaneous white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice
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cellular
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• subcutaneous mesenchymal cells exhibit reduced white adipocyte differentiation in vitro compared with wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrbtm14(Pdgfrb)Sor mutation
(1 available);
any
Pdgfrb mutation
(84 available)
Tg(Tagln-cre)1Her mutation
(2 available)
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mortality/aging
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N |
• mice exhibit normal survival
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cardiovascular system
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• mice exhibit alterations in the ascending aorta at 2 weeks that progresses through the arch and descending aorta to affect the entire thoracic and abdominal aorta by 4 weeks unlike in wild-type mice
• mice exhibit reduced periaortic adipose compared to in wild-type mice
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• authors state that mice exhibit the aorta phenotype observed in mice expressing the floxed allele and Tg(Sox2-cre)1Amc
• however, aorta histology is normal in neonates
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• increased radius
• 2-fold dilation that reaches homeostasis without rupture or apoptosis of vascular smooth muscle cells
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• at P7, retinal capillary size is increased compared to in wild-type mice
• at P12, brain capillary size is increased compared to in wild-type mice
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• pericyte coverage of brain and retinal vasculature is increased compared to in wild-type mice
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• mice exhibit increased vascular smooth muscle cell cellularity within the aorta compared with wild-type mice
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• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice
• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures
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adipose tissue
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• mice exhibit reduced periaortic adipose compared to in wild-type mice
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growth/size/body
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N |
• mice exhibit normal growth
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muscle
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• mice exhibit increased vascular smooth muscle cell cellularity within the aorta compared with wild-type mice
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• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice
• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures
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nervous system
vision/eye
cellular
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• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice
• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrbtm14(Pdgfrb)Sor mutation
(1 available);
any
Pdgfrb mutation
(84 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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normal phenotype
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• mice exhibit no distinguishable phenotype
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Analysis Tools