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Bcl6tm1.1Toka
Targeted Allele Detail
Summary
Symbol: Bcl6tm1.1Toka
Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Takaharu Okada
MGI ID: MGI:5140802
Synonyms: Bcl6yfp, YFP-BCL6
Gene: Bcl6  Location: Chr16:23783802-23807602 bp, - strand  Genetic Position: Chr16, 15.26 cM
Alliance: Bcl6tm1.1Toka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174014
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA monomeric EYFP gene was inserted into exon 1 and a floxed neo cassette was inserted upstream of exon 1. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:174014)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl6 Mutation:  33 strains or lines available
References
Original:  J:174014 Kitano M, et al., Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity. 2011 Jun 24;34(6):961-72
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory