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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl6tm1.1Toka
targeted mutation 1.1, Takaharu Okada
MGI:5140802
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl6tm1.1Toka/Bcl6tm1.1Toka involves: C57BL/6 * NZB MGI:5140807
cx2
 		Bcl6tm1.1Toka/Bcl6+
Tg(TcraTcrb)425Cbn/0 		involves: BALB/c * C57BL/6 * NZB MGI:5140808
cx3
 		Bcl6tm1.1Toka/Bcl6tm1.1Toka
Tg(IghelMD4)4Ccg/0 		involves: C57BL/6 * NZB MGI:5140809


Genotype
MGI:5140807
hm1
Allelic
Composition		 Bcl6tm1.1Toka/Bcl6tm1.1Toka
Genetic
Background		 involves: C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Toka mutation (1 available); any Bcl6 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:174014 )
N
• antibody class switching is normal
abnormal Peyer's patch morphology ( J:174014 )
• Peyer's patches contain fewer T follicular helper cells compared to in wild-type mice

hematopoietic system




Genotype
MGI:5140808
cx2
Allelic
Composition		 Bcl6tm1.1Toka/Bcl6+
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: BALB/c * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Toka mutation (1 available); any Bcl6 mutation (55 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:174014 )
• T follicular helper cells in mice immunized with NP-ovalbumin exhibit accelerated proliferatively quiescent unlike wild-type cells

hematopoietic system
decreased T cell proliferation ( J:174014 )
• T follicular helper cells in mice immunized with NP-ovalbumin exhibit accelerated proliferatively quiescent unlike wild-type cells

cellular
decreased T cell proliferation ( J:174014 )
• T follicular helper cells in mice immunized with NP-ovalbumin exhibit accelerated proliferatively quiescent unlike wild-type cells




Genotype
MGI:5140809
cx3
Allelic
Composition		 Bcl6tm1.1Toka/Bcl6tm1.1Toka
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm1.1Toka mutation (1 available); any Bcl6 mutation (55 available)
Tg(IghelMD4)4Ccg mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased activation-induced B cell apoptosis ( J:174014 )
• B cells co-transferred with Tg(TcraTcrb)425Cbn cells into wild-type mice immunized with HEL-ovalbumin exhibit increased apoptosis compared with similarly treated heterozygous cells
abnormal germinal center B cell physiology ( J:174014 )
• B cells co-transferred with Tg(TcraTcrb)425Cbn cells into wild-type mice immunized with HEL-ovalbumin exhibit impaired formation of germinal center B cell populations compared with similarly treated heterozygous cells

cellular
increased activation-induced B cell apoptosis ( J:174014 )
• B cells co-transferred with Tg(TcraTcrb)425Cbn cells into wild-type mice immunized with HEL-ovalbumin exhibit increased apoptosis compared with similarly treated heterozygous cells

hematopoietic system
increased activation-induced B cell apoptosis ( J:174014 )
• B cells co-transferred with Tg(TcraTcrb)425Cbn cells into wild-type mice immunized with HEL-ovalbumin exhibit increased apoptosis compared with similarly treated heterozygous cells
abnormal germinal center B cell physiology ( J:174014 )
• B cells co-transferred with Tg(TcraTcrb)425Cbn cells into wild-type mice immunized with HEL-ovalbumin exhibit impaired formation of germinal center B cell populations compared with similarly treated heterozygous cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory