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Targeted Allele Detail
Symbol: Pmltm1(PML/RARA)Ley
Name: promyelocytic leukemia; targeted mutation 1, Timothy J Ley
MGI ID: MGI:5014059
Synonyms: mPML-PRflox
Gene: Pml  Location: Chr9:58218076-58249786 bp, - strand  Genetic Position: Chr9, 31.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:172024
Parent Cell Line:  B6/BLU (ES Cell)
Strain of Origin:  C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
Mutation detailsA cassette, which contains a floxed neo resistance gene with five stop codons in three frames and a fusion of human PML and RARA, was inserted into the 5' untranslated region. The absence of protein expression was confirmed by western blot analysis on spleen cells. (J:172024)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pml Mutation:  60 strains or lines available
Original:  J:172024 Welch JS, et al., PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. J Clin Invest. 2011 Apr 1;121(4):1636-45
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory