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Gbp2btm1Tigm
Targeted Allele Detail
Nomenclature
Symbol: Gbp2btm1Tigm
Name: guanylate binding protein 2b; targeted mutation 1, Texas A&M Institute for Genomic Medicine
MGI ID: MGI:5013366
Gene: Gbp2b  Location: Chr3:142594847-142619179 bp, + strand  Genetic Position: Chr3, 66.69 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172364
Parent Cell Line:  Lex-2 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 4 were replaced with a neo/lacZ cassette. Reduced protein expression in IFN-gamma-activated bone marrow macrophages was confirmed by western blot analysis. (J:172364)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gbp2b Mutation:  2 strains or lines available
References
Original:  J:172364 Kim BH, et al., A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection. Science. 2011 May 6;332(6030):717-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory