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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Spyros Artavanis-Tsakonas
MGI ID: MGI:5007799
Synonyms: Gt(ROSA)26Sortm1(NOTCH3*R1031C)Sat, NOTCH3R1031C
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:171887
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat expresses 1 gene
Mutation detailsA targeting vector containing a splice acceptor site, a floxed PGK neomycin cassette, a human NOTCH3 cDNA with an R1031C mutation and an IRES-nuclear GFP sequence was inserted via homologous recombination. (J:171887)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  253 strains or lines available
Original:  J:171887 Arboleda-Velasquez JF, et al., PNAS Plus: Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A. 2011 May 24;108(21):E128-35
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory