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Fasltm1.1Bksa
Targeted Allele Detail
Nomenclature
Symbol: Fasltm1.1Bksa
Name: Fas ligand (TNF superfamily, member 6); targeted mutation 1.1, Bruce R Ksander
MGI ID: MGI:5006689
Gene: Fasl  Location: Chr1:161780689-161788495 bp, - strand  Genetic Position: Chr1, 69.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171440
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsEight residues within exon 2 were deleted resulting in a splicing error and frameshift mutation. Cre-mediated recombination used the floxed neo cassette used for selection. FACS analysis confirmed the absence of Fasl-expressing activated T cells. (J:171440)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fasl Mutation:  19 strains or lines available
References
Original:  J:171440 Gregory MS, et al., Opposing roles for membrane bound and soluble fas ligand in glaucoma-associated retinal ganglion cell death. PLoS One. 2011;6(3):e17659
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory