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Targeted Allele Detail
Symbol: Anp32btm1Mak
Name: acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; targeted mutation 1, Tak Mak
MGI ID: MGI:5003050
Gene: Anp32b  Location: Chr4:46450902-46472657 bp, + strand  Genetic Position: Chr4, 24.79 cM, cytoband B2
Kyphosis in Anp32btm1Mak/Anp32btm1Mak mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:172042
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2, 3, and 4 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:172042)
Generation of the Anp32btm1Mak allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Anp32b Mutation:  105 strains or lines available
Modifier gene(s) (unknown) linked to SNP rs6190775 on chromosome 11 alter(s) viability. J:227403
Original:  J:172042 Reilly PT, et al., Acidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development. Proc Natl Acad Sci U S A. 2011 Jun 2;108(25):10243-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory