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Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sean E Egan
MGI ID: MGI:5000472
Synonyms: R26-Pik3caH1047R
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170898
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan expresses 1 gene
 
Mutation detailsA construct consisting of a splice acceptor site, a floxed transcriptional stop cassette and a mutant mouse Pik3ca cDNA, encoding for a histidine 1047 arginine substitution, was inserted into intron 1 via homologous recombination. (J:170898)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  428 strains or lines available
References
Original:  J:170898 Adams JR, et al., Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation. Cancer Res. 2011 Apr 1;71(7):2706-2717
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory